Featured Publications

InnoTherapy thrives to develop a unique platform technology for attaining global competitiveness.
Our research activities are internationally recognized based on our outstanding academic credentials and continuous research.
Coagulopathy-independent, bioinspired hemostatic materials: A full research story from preclinical models to a human clinical trial
Keumyeon Kim, Ji Hyun Ryu, Mi-Young Koh, Sung Pil Yun, Soomi Kim, Joseph P. Park, Chul-Woo Jung, Moon Sue Lee, Hyung-Il Seo, Jae Hun Kim, Haeshin Lee
Science Advances 7 (13), eabc9992. (2021)
https://advances.sciencemag.org/content/7/13/eabc9992
Randomized trial comparing radial hemostasis techniques; catechol conjugated chitosan pad (InnoSEAL) versus pneumatic compression band
Asad Z. Pathan, Saba Aijaz, Sana Sheikh, Saadia Sattar
Catheter Cardiovasc Interv. 2021;1–7.
https://doi.org/10.1002/ccd.29578
Chitosan oral patches inspired by mussel adhesion
Ji Hyun Ryu, Ji Suk Choi, Eunsook Park, Min Rye Eom, Seongyeon Jo, Moon Sue Lee, Seong Keun Kwon, Haeshin Lee
J. Control. Release 317, 57-66 (2020)
https://doi.org/10.1016/j.jconrel.2019.11.006
Chitosan-catechol: a writable bioink under serum culture med…
Daiheon Lee, Joseph P. Park, Mi-Young Koh, Pureum Kim, Junhee Lee, Mikyung Shin, Haeshin Lee
Biomaterials Sci. 6, 1040-1047 (2018)
https://doi.org/10.1039/C8BM00174J
Targeting protein and peptide therapeutics to the heart via …
Mikyung Shin, Hyang-Ae Lee, Mihyun Lee, Yoomi Shin, Ji-Joon Song, Sun-Woong Kang, Dae-Hwan Nam, Eun Je Jeon, Mira Cho, Minjae Do, SunHyun Park, Moon Sue Lee, Jae-Hyung Jang, Seung-Woo Cho, Ki-Suk Kim, Haeshin Lee
Nature Biomed. Eng. 2, 304-317 (2018)
https://doi.org/10.1038/s41551-018-0227-9
Dynamic bonds between boronic acid and alginate: hydrogels w…
Sang Hyeon Hong, Sunjin Kim, Joseph P. Park, Mikyung Shin, Keumyeon Kim, Ji Hyun Ryu, Haeshin Lee
Biomacromolecules 19, 2053-61 (2018)
https://doi.org/10.1021/acs.biomac.8b00144
Hemostatic ability of chitosan-phosphate inspired by coagulation mechanisms of platelet polyphosphates
Younseon Wang, Keumyeon Kim, Moon Sue Lee, Haeshin Lee
Macromol. Biosci. 18, e1700378 (2018)
https://doi.org/10.1002/mabi.201700378
Hemostatic swabs containing polydopamine-like catecholamine chitosan-catechol for normal and coagulopathic animal models
Mikyung Shin, Ji Hyun Ryu, Kyuri Kim, Min Jun Kim, Seongyeon Jo, Moon Sue Lee, Dong Yun Lee, Haeshin Lee
ACS Biomater. Sci. & Eng. 4, 2314-18 (2018)
https://doi.org/10.1021/acsbiomaterials.8b00451
Complete prevention of blood loss with self-sealing haemostatic needles
Mikyung Shin, Sung-Gurl Park, Byung-Chang Oh, Keumyeon Kim, Seongyeon Jo, Moon Sue Lee, Seok Song Oh, Seon-Hui Hong, Eui-Cheol Shin, Ki-Suk Kim, Sun-Woong Kang, Haeshin Lee
Nature Mater. 16, 147-152 (2017)
https://doi.org/10.1038/nmat4758
TAPE: A biodegradable hemostatic glue inspired by a ubiquitous compound in plants for surgical application
Keumyeon Kim, Haeshin Lee, Seonki Hong
J. Visual. Exp. 112, e53930 (2016)
https://doi.org/10.3791/53930
PEGylation and HAylation via catechol: α-amine-specific reaction at N-terminus of peptides and proteins
In Taek Song, Mihyun Lee, Hyukjin Lee, Jinah Han, Jae-Hyung Jang, Moon Sue Lee, Gou Young Koh, Haeshin Lee
Acta Biomater. 43, 50-60 (2016)
https://doi.org/10.1016/j.actbio.2016.07.018
Tannic acid as a degradable mucoadhesive compound
Mikyung Shin, Keumyeon Kim, Whuisu Shim, Jae Wook Yang, Haeshin Lee
ACS Biomaterials Sci. & Eng. 2, 687-696 (2016)
https://doi.org/10.1021/acsbiomaterials.6b00051
TAPE: a medical adhesive inspired by a ubiquitous compound in plants
Keumyeon Kim, Mikyung Shin, Mi-Young Koh, Ji Hyun Ryu, Moon Sue Lee, Seonki Hong, Haeshin Lee
Adv. Funct. Mater. 25, 2402-2410 (2015)
https://doi.org/10.1002/adfm.201500034
DNA/Tannic acid hybrid gel exhibiting biodegradability, extensibility, tissue adhesiveness, and hemostatic ability
Mikyung Shin, Ji Hyun Ryu, Joseph P. Park, Keumyeon Kim, Jae Wook Yang, Haeshin Lee
Adv. Funct. Mater. 25, 1270-78 (2015)
https://doi.org/10.1002/adfm.201403992
Adhesive barrier/directional controlled release for cartilage repair by endogenous progenitor cell recruitment
Jong Min Lee, Ji Hyun Ryu, Eun Ah Kim, Seongyeon Jo, Byung-Soo Kim, Haeshin Lee, Gun-Il Im
Biomaterials 39, 173-181 (2015)
https://doi.org/10.1016/j.biomaterials.2014.11.006